CRP (C-reactive protein)

The biomarker of choice to aid the diagnosis of infection and inflammatory disorders

Request more info about biomarkers
I would like to know more about Radiometer biomarkers

Infection (PCT, CRP) Myocardial infarction (TnI, CKBM, Myo) Heart failure (NT-proBNP) Pregnancy (ßhCG) Venous thromboembolism (D-dimer)

Contact Info
Name

Job function

E-mail

Phone number

I agree to receive news and information from Radiometer. I understand that I can opt-out any time. Please contact me by phone

Workplace Details
Hospital / Institution

Department

State

ZipCode

Country

Message

By submitting this form, I acknowledge that I have reviewed and understood the data privacy notice.

All fields must be filled!
See more products

Fast results
Early detection of inflammation
Evaluation of infection

CRP testing in the emergency department

When a patient is admitted with signs and symptoms of an infection, a C-reactive protein (CRP) test is used as an aid in the detection and evaluation of infection, tissue injury, inflammatory disorders, and associated diseases. CRP is valuable as an inflammation marker at the point-of-care, primary care and lab settings.

Increased CRP levels could be associated with bacterial, viral and fungal infections, sepsis, various forms of arthritis and several other infectious and inflammatory conditions [1]. CRP is an acute-phase protein produced by the liver and released into the blood a few hours after the onset of an infection, inflammation or tissue injury.

Because of the non-specific nature of the acute-phase response which leads to increased CRP levels, CRP should be used as a diagnostic aid in the clinical assessment of a patient [2].

Immunoassay products and solutions

CRP (C-reactive protein)

D-dimer

NT-proBNP

Procalcitonin (PCT)

Troponin I

CRP (C-reactive protein)

CRP values for evaluation of infection

When faced with a patient with signs and symptoms of an infection, the physician faces the clinical dilemma of:

Administering antibiotics in a timely manner [3].
Avoiding inappropriate usage of antibiotics. Misuse of antibiotics when not required has contributed to the problem of multiresistant bacterial infections, which are very difficult to treat [4].

Interpreting the CRP value

Clinical cut-offs can be used to determine if the infection is bacterial or viral [5].

CRP test on the AQT90 FLEX analyser

The AQT90 FLEX immunoassay analyser is a benchtop analyser that brings rapid biomarker assessment capabilities right to the patient’s bedside.

The AQT90 FLEX analyser delivers quantitative results on the CRP assay in less than 13 minutes, accelerating infection and inflammatory disorder diagnosis in the ED to support rapid clinical decision making.

The AQT90 FLEX CRP assay can be used both in the lab and at the point of care without any sample or assay preparations, providing a fast result without any exposure to blood. Its closed tube system makes CRP testing easy: the operator simply inserts the sample tube into the tube holder in the sample port and the analyser performs all assay steps automatically.

All necessary reagents are included in the test cartridges, which remain stable onboard the analyser for 20 days ensuring maximum availability and uptime.

Learn more about the AQT90 FLEX analyser

Key benefits of CRP on the AQT90 FLEX analyser

No blood exposure: Closed system
No sample or assay preparation
Sample types: EDTA and lithium-heparin
Specimen types: Venous whole blood and plasma
Sample tubes: Fits most 13 × 75 mm standard tubes
No presence of hook effect, carry-over or known interferences

CRP assay specifics

Turnaround time:

< 13 min.

CV % (plasma): Within-lab CV% at conc. 7.4 mg/L: 5.3%

95th percentile*: < 5 mg/L

Traceability: Standardisation: Calibration is traceable to ERM - DA472/IFCC.

* This value should only be used as an example. Each laboratory should establish its own decision threshold level.

References

1. Testing. com. C-Reactive Protein (CRP) Test. https://www.testing.com/tests/c-reactive-protein-crp/. Accessed July 2022.
2. Seeger C et al. Acute care testing handbook 2014.
3. Joo YM et al. Impact of timely antibiotic administration on outcomes in patients with severe sepsis and septic shock in the emergency department. Clinical and Experimental Emergency Medicine 2014;1, 1.
4. Lee Ventola C. The Antibiotic Resistance Crisis Part 1: Causes and Threats. P&T 2015; 40, 4.
5. Review Criteria for Assessment of C Reactive Protein (CRP), High Sensitivity C-Reactive Protein (hsCRP) and Cardiac C-Reactive Protein (cCRP) Assays - Guidance for Industry and FDA Staff. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/review-criteria-assessment-c-reactive-protein-crp-high-sensitivity-c-reactive-protein-hscrp-and. Assessed Dec 2020.

Cookies are used on this website

Use of cookies

Don't show this message again

Radiometer is using Microsoft AZURE Active Directory to authenticate users

Radiometer uses Azure AD to provide our customers and partners secure access to documents, resources, and other services on our customer portal.

If your organization is already using Azure AD you can use the same credentials to access Radiometer's customer portal.

Key benefits

Allow the use of existing Active Directory credentials
Single-sign on experience
Use same credentials to access future services

Request access

You will receive an invitation to access our services via e-mail when your request has been approved.

When you accept the invitation, and your organization is already using AZURE AD, you can use the same credentials to access Radiometer's customer portal. Otherwise, a one-time password will be sent via e-mail to sign in.

Effective Date January 20th, 2023 (last updated January 20th, 2023)

ABOUT THIS POLICY

Radiometer values your privacy and the protection of your personal data. This policy (“Policy”) explains how Radiometer its affiliates, subsidiaries or related companies, a full list of which can be located here (together, “Radiometer,”, “our”, “us,” or “we”), collects, uses, shares, transfers and processes data collected from or about you.

“Personal Data” is any information that can be used to directly or indirectly identify an individual or that can be reasonably expected to link to an individual. This can include items such as name, address, telephone number, credit card details, email address, ID number, Internet Protocol (“IP”) address of an electronic device used by an individual, or other identifying code (even absent of other identifying information). Statistical and non-identifiable metric data are not considered Personal Data.

The Radiometer subsidiary, affiliate or related company with which you interact is, where applicable, the data controller (or equivalent under applicable law) responsible for the processing of your Personal Data. You can find a list of the relevant legal entities that act as data controllers in Appendix 1 to this Policy.

SCOPE

This Policy describes the types of Personal Data that we may collect, process or disclose about you and how you may govern this processing by exercising applicable legal rights. This Policy applies to both online and offline information collection, including your use of websites or subdomains operated by us, any mobile applications, when we provide products and/or services to you or notify you about prospective items of interest and in other situations where you interact with us in-person, by telephone or by mail where this Policy is posted or referenced.

There may be occasion where you have been provided with a circumstance-specific privacy notice that is separate from this policy, such as privacy notices for specific activities such as Recruitment. To the extent you were provided with a different notice, those notices apply and govern our interactions with you. If you provide Personal Data about parties other than yourself, you are responsible for ensuring their knowledge of how we will process their personal data, and, where applicable, obtaining any necessary consents required in advance.